Neurokinin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum

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Neurokinin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum.

The regulation of neostriatal cholinergic function by tachykinins (TKs) has been studied by measuring endogenous ACh released from rat neostriatal slices. Septide (SEP; a highly selective substance P analog), neurokinin A (NKA), and neurokinin B (NKB) elicited endogenous ACh release in a concentration-dependent manner. The rank order in potency was the following: NKB (EC50 approximately 0.5 nM)...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1991

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.11-08-02332.1991